Consider collaborating with existing registry programs or creating local registries to find potential volunteers. Incorporate trial-ready cohort programs, such as TRC-PAD and EPAD, into the screening model as a method of high-efficiency enrollment.
Enhancing Study Site Capacity
Goal: Create the capacity of study sites and research organizations to increase enrollment for an ever-growing portfolio of Alzheimer’s disease and related dementias studies.
Ideas in this area might address:
- Infrastructure investments needed to enhance capacity of sites to accommodate growing number of studies and participants
- Systems to improve recruitment efficiency
- Collaboration – with communities, other institutions and study sites, organizations and agencies
- Workforce diversity, training, and capacity
- Changes in culture or valuation of clinical research in organizations
- Effective use of registries
- Role of funders, organizations, policymakers in implementing
Run multiple, complementary studies at a site so that screening efforts are not specific to one trial and can offer more than one research participation option for many volunteers, such as those at varying stages of disease.
Establish a community screening center or offer a financial incentive to sites that can pre-screen for studies beyond their own investigations. Additional required informed consents should apply to all disease stages and trial interventions; locate such sites near principal investigator sites.
Support site collaboration and communication around site-level recruitment, including the use of public-private partnerships with support from industry, to link local sites to promote this kind of effort. Fund trial or site-agnostic outreach efforts. Allow sites to use funding from a single sponsor to help support recruitment for multiple studies.
This could include: 1) Identifying the project’s target populations and develop a staffing and outreach strategy that is appropriately sensitive to this goal. 2) Developing employment descriptions that capture relevant experiences with the target communities and specialized skills (e.g. language facility, familiarity with the community). 3) Identifying opportunities to leverage staffing resources from other academic ...more »
Offer community programs not targeted specifically to research recruitment (e.g., brain health/fitness, cardiovascular/diabetes risk, and memory screening). Ensure that recruitment staff connect with families and potential participants before discussing research. Ensure when feasible that a budget and plan exist to expand a site’s capacity to serve the community as a resource.
Develop nimble staffing models to respond to fluctuations in recruitment needs and to minimize staff burden and risk of burnout during periods of heavy enrollment.
Invest in creating a community advisory board as part of the site team to help guide recruitment.
Provide viable career paths and opportunities for professional advancement for all staff in the recruitment workforce. For example, develop clinical research tenure tracks and create awards to recognize clinical trials and studies excellence, including consideration of listing top recruitment staff as authors in research papers.
Build the cost of full-time recruitment staff or a team into grant application budgets. Hire at each site or cluster of sites a recruiter or recruitment team that includes backgrounds in public health marketing and outreach, as well as those with skills in recruiting families who are experiencing cognitive decline in a loved one. Support site-level efforts to retain experienced coordinators, raters, regulatory staff, ...more »
Fiscally reward high-enrolling sites (e.g., cover start-up costs, set enrollment targets from the outset, and offer financial gain for reaching targets).
Develop site and system business processes that support a robust, efficient clinical research infrastructure. These processes may include use of stable funding models not linked to per-subject recruitment revenue for leadership, outreach and recruitment, as well as practices that support streamlined clinical trials.